Literature summary for 1.1.1.428 extracted from

Kumar, V.; Carlson, J.; Ohgi, K.; Edwards, T.; Rose, D.; Escalante, C.; Rosenfeld, M.; Aggarwal, A.
Transcription corepressor CtBP is an NAD+-regulated dehydrogenase (2002), Mol. Cell., 10, 857-869 .

Search for more literature for 1.1.1.428

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in BL-21(DE3) pLysS cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
selenomethionine-substituted enzyme bound to NAD+, using 140 mM sodium formate, 70 mM magnesium acetate, and 100 mM HEPES (pH 7.0)	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D204A/G181V/G183V	the mutations strongly inhibit the enzyme's ability to bind E1A and NAD+. The mutant is defective in catalysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-affinity column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + NADH + H+	-	Homo sapiens	lactate + NAD+	-	?

Subunits

Subunits	Comment	Organism
?	x * 47500, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
C-terminal binding protein 1	-	Homo sapiens
CTBP1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	dependent on	Homo sapiens
NADH	dependent on	Homo sapiens

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Release 2023.1 (January 2023)